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As an example, consumption of large doses of aflatoxins can result in life-threatening, acute poisoning (aflatoxicosis) due to detrimental impact on the liver

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These findings suggest that after the loss of dopaminergic neurons, a vicious cycle of decreased dopamine releaseDRD2 signaling deficiencydecreased GSH synthesisoxidative stressdopaminergic neuron death will occur, leading to GSH deficiency and the progression of PD