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The genuine human Phase II trials used full-length thymosin beta-4 as a topical eye drop for dry eye, and even those had mixed results on their primary endpoints

This is due to differences in the position of a proline in TM2 (Supplementary Fig

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Low levels of FLNA, causing loss of coupling of SSTR2 with downstream signal transduction molecules, might explain the resistance to SS analogs in GH-secreting pituitary tumors even if in the presence of SSTR2