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Exclusion criteria included any pharmacological treatment of the gastrointestinal tract, systemic antibiotics within the last 3 months, probiotics or low-FODMAP-diet within the last 3 weeks, vegan or vegetarian diet, regular use of analgesics, pregnancy, prior gastrointestinal surgery apart from appendectomy (16)
The combination of low intracellular GSH levels and low expression of ABCC1 and ABCC2 in proliferative endothelial cells accounts for GSAO selectivity and subsequently for GSAO anti-angiogenic properties (Park and Dilda, 2010)
In addition, SOD was measured using specific colorimetric assay kits (Arbor Assays Company, 1514 Eisenhower Place Ann Arbor, Michigan 48108 USA, Catalog Number K028-H1), while GPx was measured using particular colorimetric assay kits (BioAssay Systems Company, Hayward, CA 94545, USA, Catalog Number: EGPX-100) following the manufacturers instructions for each test
Several uricosuric drugs exert their effects by interferring with uric acid transport primarily via proximal tubule reabsorption
