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(2023): Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes

By stimulating insulin release and inhibiting glucagon, Tirzepatide helps stabilize blood sugar levels, reducing the risk of hyperglycemia, insulin resistance, and type 2 diabetes

I looked at the Japanese studies, and what I found was even in that author that you mention, if you looked at it, there was a considerably and there were two cities in Japan where they did a comparison

If the primary goal is weight loss without underlying metabolic conditions, lifestyle changes like diet and exercise may be more effective in the long run

There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells