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After establishing the basal level of extracellular dopamine, peptide treatments were injected ( i.c.v .) through the guide cannula, and five more dialysate samples were collected after the administration to evaluate the peptide effect on extracellular dopamine level

Overall the study concluded that AOD9604 was shown to be beneficial in obese mice both with and without the beta(3)-adrenergic receptors present

Khafagy et al., 2009a)

However, the predominance of in vitro and acute in vivo models highlights the need for systematic evaluation of long-term safety, biodistribution, and translational relevance in clinically relevant neurological settings [151153]

Generation of functional human hepatic endoderm from human induced pluripotent stem cells