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Glossary AC Adenylate cyclase AMFR Autocrine motility factor receptor AMPK AMP-activated protein kinase ARE Antioxidant response element ATF4 Activating transcription factor 4 ATF6 Activating transcription factor 6 cAMP Cyclic adenosine monophosphate CHOP C/EBP homologous protein cryo-EM Cryogenic electron microscopy DAG Diacylglycerol DPP-4 Dipeptidyl peptidase-4 ECD Extracellular domain Epac2 Exchange protein directly activated by cAMP 2 ER Endoplasmic reticulum ETC Electron Transport Chain FFAs Free fatty acids GLP-1 Glucagon-like peptide-1 GLP-1R Glucagon-like peptide-1 receptor GLP-1RA Glucagon-like peptide-1 receptor agonist GPCR G protein-coupled receptor GRP75 Glucose-regulated protein 75 GSIS Glucose-stimulated insulin secretion IP3 Inositol 1,4,5-trisphosphate IP3R Inositol 1,4,5-trisphosphate receptor LLPS Liquid-liquid phase separation MASH Metabolic dysfunction-associated steatohepatitis mtCU Mitochondrial calcium uniporter complex MCS Membrane contact site MERCS Mitochondria-ER contact sites MFN2 Mitofusin 2 MICOS Mitochondrial contact site and cristae organizing system mPTP Mitochondrial permeability transition pore NADH Nicotinamide adenine dinucleotide (reduced form) Nrf2 Nuclear factor erythroid 2-related factor 2 OMM Outer mitochondrial membrane ORP Oxysterol-binding protein-related protein OXPHOS Oxidative phosphorylation PE Phosphatidylethanolamine PISD Phosphatidylserine decarboxylase PKA Protein kinase A PS Phosphatidylserine RAiNs Receptor-associated independent nanodomains ROS Reactive oxygen species S1R Sigma-1 receptor T2DM Type 2 diabetes mellitus TBK1 TANK-binding kinase 1 TMD Transmembrane domain UPR Unfolded protein response VAPB Vesicle-associated membrane protein-associated protein B VDAC Voltage-dependent anion channel References 1 Abdrabou AbouelmagdA.AbdelrehimA

2013;5:a008656

Blood Sugar and Metabolic Effects Blood sugar regulation is relevant in tirzepatide vs semaglutide discussions

Synthesized peptides were characterized by LC-MS and MALDI-TOF analyses

During this time, Eliquis is projected to generate approximately $39.1 billion in U.S