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A number of scholars have invoked the precautionary principle to call for action in the face of uncertainty on a range of public health and environmental protection issues.[92] The precautionary principle has been set out in the Rio Declaration on Environment and Development as: Where there are threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost-effective measures. [93] By this principle, gaps in scientific evidence on the harms of certain aspects of childrens work in tobacco farming should not be used as a reason to delay taking cost-effective preventive action to protect children from the plausible threats to their health posed by work in the crop