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It should be used with caution in patients with severe, pre-existing mitochondrial disease

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Oral semaglutide requires strict fasting conditions due to its low bioavailability, whereas orforglipron can be taken at any time of day without food or water restrictions

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Previously, a double-blind clinical trial reported that the co-ingestion of 120 mg of a Ginkgo biloba extract together with 500 mg metformin did not significantly change the metabolism of metformin in healthy individuals or in individuals with type 2 diabetes mellitus (Kudolo 2006)

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