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In another short-term drinking water study, calcification in kidney tubules between the cortex and medulla was observed in 3 of 5 rats administered 3,335 mg/kg/day glycerol in drinking water for 6 months (CIR, 2014)

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Of particular note, the significant accumulation of 5-methyl-2-furanmethanol (with a caramel-like aroma) and damascone (with a fruity-floral aroma) in FS2 corresponded directly to the high scores for caramelized and nutty aromas in sensory evaluations, establishing a clear link between specific volatile compounds and their perceived sensory attributes (Fig