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Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation
If additional treatment is needed, your healthcare provider will recommend the most appropriate schedule
Additional proposed mechanisms include modulation of dopaminergic and serotonergic neurotransmission
Diagnosing hypothyroidism will likely require you and your healthcare provider to look beyond the thyroid gland itself
Antioxidants (Basel) 9:980
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