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These medications work by reducing hunger, slowing stomach emptying, and altering food preferences, which can lead to lower calorie intake and, in some cases, unintended side effects such as nausea, constipation, and loss of lean muscle mass

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High dietary intakes methionine (56 g/day) on the other hand have been shown to raise plasma levels of homocysteine, despite adequate intakes of B vitamins [3133]