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The oral NMDA receptor positive allosteric modulator zelquistinel (AGN-241751, GATE-251) [100] was investigated in a phase 1/2 trial (NCT03726658) and a phase 2 trial (NCT03586427) for the treatment of MDD, but the studies did not meet their primary efficacy endpoints

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& Van Den Bosch, L

By the end of this article, you'll understand the key mechanistic differences, what human clinical data actually shows, how to layer both safely, and which ingredient is the right call for your skin type and goals

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