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The PI3K-Akt pathway is a well-established signal transduction pathway that regulates various cellular processes, including metabolism, survival, and vascular function

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An intravenous catheter (Abbocath G18) was placed in the jugular vein to facilitate administration of drugs used for the treatment and an intravenous catheter (Abbocath G22) was placed in antebrachial cephalic vein for sampling the blood

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