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This cellular response is referred to as necrosis, and as stated by Edinger and Thompson 33 , is the end result of a bioenergetic catastrophe to a level incompatible with cell survival

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PubMed Central , Methods in Molecular Biology (Clifton, N.J.) , vol

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Improper technique or contamination can lead to more serious localized issues such as injection site infection, abscess formation, tissue necrosis, or thrombophlebitis (vein inflammation)