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Targeting glutamine metabolism transporter inhibitors Gln metabolism has received increasing attention in the process of material transport and energy metabolism in cancer cells, and increased Gln catabolism in cancer cells has been associated with increased expression of Gln transporter proteins

The following sgRNAs for GCLC CRISPRCas9 KO were used: sgNTC forward: 5-CACCGGAGGCTAAGCGTCGCAA-3

doi: 10.3389/fphar.2023.1255501 Received 08 July 2023 Accepted 04 August 2023 Published 17 August 2023 Volume 14 - 2023 Edited by Weijie Xie, Shanghai Jiao Tong University, China Reviewed by Xiang Dong Du, Suzhou Psychiatric Hospital, China Shen Li, Tianjin Medical University, China Updates Copyright 2023 Zhao, Liu, Wang, Wang, Xiu and Li

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Linearity and stability of intravenous busulfan pharmacokinetics and the role of glutathione in busulfan elimination