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demonstrated that ferritin delivery to lysosomes requires NCOA4, and NCOA4-deficient cells fail to degrade ferritin, leading to a reduction in bioavailable intracellular iron (53)

This means that GABAs dampening effects are strengthened, and therefore more able to slow or inhibit more excitatory nerve impulses traveling along the CNS

Neurochem Int (2019) 128:3949

Quantitation of urinary carnitine esters in a patient with medium-chain acyl-coenzyme A dehydrogenase deficiency: effect of metabolic state and L-carnitine therapy