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It can be involved in helping to maintain normal protein structures in the body, marking certain molecules for elimination as waste in the liver, and in important enzymatic reactions necessary to neutralize potentially harmful free radicals throughout the body

These can result in local infections, systemic inflammation, or unexpected endocrine consequences

The 2006 clinical study noted this theoretical concern but did not observe pituitary desensitization within its study window

It is a primary constituent of collagen, making up over one-third of the total amino acids in this key structural component of blood vessels, skin, bones, cartilage, tendons, ligaments, and other connective tissue

Elacestrant is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ER and ER, respectively