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and even as they account for less than 1% of the intestinal epithelium, they establish a complex signaling network, that is likely to be the first step of integration, involving the information obtained from the gut lumen (63, 88, 89)

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7 Pharmacokinetic/Pharmacodynamic Relationships Based on data from a phase III study in the USA, as well as a dose-finding phase II study, the mean change from baseline in HbA 1c at 1214 weeks was plotted for various doses of liraglutide (up to 1.8 mg and including placebo) given as monotherapy [33]

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