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10.1016/j.amjmed.2009.11.019 7 BaraboiE

This step can be done inhouse or outsourced to CMOs

The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell

Two therapeutic strategies targeting xCT were highlighted in this review, that is, directly inhibiting xCT activity and targeting glucose/glutamine dependency as a therapeutic vulnerability in xCT-overexpressing cancer cells

And for generations, women accepted it as part of life