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Abbreviations CVD: Cardiovascular disease HF: Heart failure HFrEF: Heart failure with reduced ejection fraction IV: Intravenous ID: Iron deficiency TSAT: Transferrin saturation FCM: Ferric carboxymaltose DCYTB: Duodenal cytochrome B CRT: Cardiac resynchronization therapy CMR: Cardiac magnetic resonance ROS: Reactive oxygen species ATP: Adenosine triphosphate Fe: Iron FPN: Ferroportin sTfR: Soluble transferrin receptor TIBC: Total iron-binding capacity HIF: Hypoxia-inducible factor IL: Interleukin eNOS: Endothelial nitric oxide synthase HFE: Hemochromatosis gene AHA: American Heart Association ACC: American College of Cardiology HFSA: Heart Failure Society of America ESKD: End-stage kidney disease References WHO

Common Side Effects Swelling Bruising Tightness or numbness under the chin Mild discomfort Temporary skin irregularities These usually resolve within 13 weeks

Participants took their last dose of GLP-1 medication at least 3 days but no more than 10 days before starting tirzepatide

The changes in 20242025 reflect that philosophy: ensuring MA enrollees get what theyre entitled to (no more, but also no less), and that plans compete on value rather than on cherry-picking or marketing tricks