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Classified as the smallest functional units within peptide categories (ultrashort: 2-9, short: 10-24, medium: 25-50, long: 50-100 amino acids) 27 , 28 , tripeptides offer unique therapeutic benefits, including enhanced tissue penetration, reduced immunogenicity, and improved cellular uptake 25 , 29 - 31
This genomic flexibility, coupled with specific mutations in drug targets, overexpression of efflux transporters, and alterations in sterol biosynthesis pathways, enables Leishmania to withstand various therapeutic interventions and develop resistance to multiple drugs
Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study
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