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Thus, prolonged methionine deprivation mitigates the cellular stress and oxidative damage that would otherwise lead to ferroptosis, providing a cellular protective mechanism against the induction of this form of cell death (Xue et al., 2023)

Increased epigenetic marks (H3K27ac, H3K4me3, H3K4me1) were associated with primed-microglia in Parkinson's disease (Huang et al., 2023) and AD (Wendeln et al., 2018), and glycolysis/H4K12la/PKM2 positive feedback loop exacerbated microglial dysfunction (Pan et al., 2022)

Nothing in this article constitutes medical advice, a treatment recommendation, or a claim of therapeutic benefit

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Japan SLC, Hamamatsu, Japan) were housed under controlled temperature (approximately 23C), humidity (approximately 55%), and light (12 h/12 h light/dark cycle) conditions, and fed a regular diet (CRF-1