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It means the risk profile differs depending on the route, dose, and individual factors

But there is something else, right, because there is this group at the Stanford, Tony Wyss-Coray or something

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Articular cartilage is a connective tissue composed of chondrocytes and an extracellular matrix of water, high-molecular-weight proteoglycans and collagen

However, long-term use in supraphysiologic doses can suppress the HPAA and consequently cause GIAI