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Although the relationship between glutathione depletion, mitochondrial dysfunction and neuronal cell death needs further exploration, seemingly the clinical improvements in PD patients who are treated with IV glutathione in addition to their traditional medications warrants consideration in appropriate PD patients.

(Figure 3B), which is consistent with our previous results

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22,149,150 TSC1 acts as a regulator of the stability of TSC2, preventing the degradation of TSC2, while TSC2 is a GTPase activating protein (GAP) that inactivates Rheb, a GTPase of the Ras family, and other small G proteins