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In addition, Lf can also regulate cytokine synthesis by modulating gene expression (i.e., by blocking the NF-kB): in particular Lf down regulate the levels of some pro-inflammatory cytokines, such as interleukin 1, tumor necrosis factor (TNF-), interleukin 6 and interleukin 8 (Sabra and Agwa 2020), and it up regulate the production of anti-inflammatory interleukin 10 (IL-19) (Hwang et al
Given the complex interplay between metabolism, bone development, cell differentiation, and the gut microbiota during growth, these pharmacological interventions must be applied with caution and supported by robust longitudinal evidence
Data Source We used the TriNetX database, a multicenter federated health research network that aggregates anonymized data from electronic health records (EHRs) drawn from more than 120 participating health care organizations, including academic medical centers, specialty physician practices, and community hospitals, covering approximately 275 million patients
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