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Mir Ali, MD, board certified bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, who was not involved in the study, said: As far as I know, no definite mechanism to link GLP-1 medications and suicidal ideation [has been described]. He also said, There is disagreement because the incidence [of suicidal ideation] is so rare that it is difficult to accurately assess and try to delineate a possible reason for this. Separating existing psychological stressors from those possibly caused by GLP-1 is also difficult

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