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For example, mitochondrial dysfunction is prevalent in both idiopathic ASD (31) and is associated with Rett syndrome (3234), PTEN mutations (35), Phelan-McDermid syndrome (36), 15q11-q13 duplication syndrome (37, 38), Angelman syndrome (39), Septo-optic dysplasia (40), and Down syndrome (41, 42)

Separation of macrovascular signal in multi-inversion time arterial spin labelling MRI

Other downstream effects include reduced glutathione antioxidant levels leading to oxidative stress, increased intracellular calcium, and ER stress leading to protein aggregation of TDP-43, SOD1, and FUS [8, 311]

Archives of Physiology and Biochemistry