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Excess body fat, particularly around the midsection, promotes insulin resistance

While semaglutides safety data is reassuring, metformins track record is longer

Stopping prematurely risks incomplete healing and return of problems

Cold Sensitivity as a Side Effect: What Clinical Trials Show Large randomized trials of tirzepatide (SURMOUNT-1, SURMOUNT-2, and SURMOUNT-3) documented gastrointestinal side effects like nausea and vomiting most frequently, but cold sensitivity did not appear in the primary adverse event lists

The most common side effects are nausea, constipation, stomach pain, diarrhea and vomiting that often get better over time