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In contrast, in a trial among more than 200 Chinese patients with various cancers who had peripheral neuropathy from previous chemotherapy, those who took ALC were more likely than those who took a placebo to have an improvement of at least one grade in their neuropathy

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Pregabalin , a ligand of the 2- subunit, is the drug with the most positive studies showing at least a 3050% improvement in neuropathic pain

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A doctor might do this if theres no approved medication to treat the patients condition or the patient has tried all other approved drugs without their condition improving