Progress on modulating tumor-associated macrophages with biomaterials
doi:10.1111/dom.15292 Pasternak B, Wintzell V, Hviid A, Eliasson B, Gudbjrnsdottir S, Jonasson C, et al
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Interestingly, tamoxifen acting mostly as an anti-estrogen compound has potential for causing cognitive side effects (Novick et al., 2020), given the neuroprotective property of central estrogen, but the true effects of tamoxifen as an estrogen antagonist or agonist appear to depend on the background concentration of endogenous ligand (partial agonist at low estrogen concentration, for example,) (Paige et al., 1999)