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Pre-treatment considerations should include: Disease activity assessment : GLP-1 agonists should ideally be initiated when Crohn's disease is in remission or well-controlled, as distinguishing medication side effects from disease flare becomes challenging during active inflammation Nutritional status evaluation : Patients with Crohn's disease may already have compromised nutritional status

This intramuscular route achieves consistent, predictable drug levels week to week, eliminating variability from individual differences in stomach pH, digestive enzyme activity, or intestinal permeability that can influence oral medication absorption

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However, titrating weight loss medications, such as semaglutide, is necessary to ensure that your body adjusts to the new medication