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GLP-1R is expressed in feeding-related nuclei in the hypothalamus and brainstem (47, 48), and knockout from glutamatergic but not GABAergic neurons almost entirely abrogates GLP-1R agonist-induced weight loss in obese mice (49)

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So, clinicians often look at weight trend over time, not just one number on a scale

Starting in 2008, large cardiovascular outcome trials (CVOTs) have been carried out to test the safety and efficacy of new glucose-lowering agents, revealing the cardiovascular protective actions of glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs)

Researchers are studying alternate dosing schedules and higher doses