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Highlights of Prescribing Information: Zepbound (tirzepatide) injection, for subcutaneous use

Given the snake-oil nature of weight loss claims, the billion-dollar question is whether these drugs work

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Summary: Current evidence does not establish a definitive causal relationship between weight loss injections (GLP-1 receptor agonists) and pancreatitis, though UK regulatory guidance lists pancreatitis as a potential adverse effect requiring monitoring

Exercise induces the release of myokines, such as apelin and irisin, alongside increased levels of BDNF ( GLP-1RAs act on overlapping hypothalamic circuits, reducing appetite and improving energy balance and have been shown to promote browning of white adipose tissue, contributing to increased energy expenditure