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Their widespread use for diabetes, obesity, and cardiometabolic health has naturally drawn attention far beyond their original indications

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If side effects are problematic, your doctor can discuss alternatives, including: Dose adjustment or slower titration Switching to a different GLP-1 receptor agonist Alternative diabetes medications with different mechanisms of action Additional treatments to manage specific symptoms According to NICE guidance on type 2 diabetes management (NG28), treatment decisions should be individualised, balancing efficacy, side effects, patient preferences, and overall quality of life

Alternatively, the possibility exists that hypergastrinemia that usually accompanies H

(ii) suppression of hepatic SHBG production, thereby increasing free testosterone