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Physiological Factors: These involve the effects of gastrointestinal fluids, the transportation of the drug within the gastrointestinal tract, the surface area and local blood flow at the absorption site, the impact of drug metabolism, and intestinal microbiota

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Glutathione fights those free radicals, preventing the enzyme tyrosinase from acting upon the production of melanin

Store at controlled room temperature or as directed by the compounding pharmacy

As ambulatory care pharmacists, there are a few things we can do in addition to the strategies above to help our patients through these shortage issues