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This neuroadaptation happens gradually at the cellular level and cannot be rushed, explaining why side effects persist for 6-12 weeks even though you feel the medication working immediately

Cancer Lett 188:8593 Hazra B, Kumar B, Biswas S et al (2005) Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation

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GLP-1 medications work by mimicking the natural hormone that reduces appetite, slows digestion so you feel full longer, and helps regulate blood sugar levels

Taken together, all these issues make less weight loss an expected finding in SELECT, compared with STEP 1