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This very concern dictates the use of the iPLEDGE system, a computer-based risk management program designed to help eliminate fetal exposure to isotretinoin, even if low doses are being used to treat oily skin

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181,182 Although findings from clinical trials in Parkinson disease patients are somewhat inconsistent, deep brain stimulation appears to induce some improvement in depression and anxiety symptoms in some patients, with a greater effect in the short- and medium-term

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