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However, administration and adherence is only one piece of the puzzle

Mai QG, Zhang ZM, Xu S, Lu M, Zhou RP, Zhao L, Jia CH, Wen ZH, Jin DD, Bai XC (2011) Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats

Incidence of the composite endpoint of myocardial infarction, coronary revascularization, hospitalization for heart failure, stroke or cardiovascular death was lower in the intensive treatment group (HR 0.88, 95% CI 0.780.99), with no interaction observed based on diabetes status or age

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Conservative dosing and careful monitoring are essential.