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These effects contribute to weight loss that varies by agent and dosetypically ranging from 5-8% with liraglutide 3 mg (Saxenda), up to 15% with semaglutide 2.4 mg (Wegovy), and potentially up to 20% with higher doses of tirzepatide (Zepbound)

Understanding what to expect and how to manage each side effect transforms the experience from alarming to manageable

For instance, a study found that obese patients who took the semaglutide for 68 weeks on average weight loss dropped 15% of their body weight

[2] See, e.g ., FDA, Warning Letter to Expert Aesthetics (Sep

These medications are not appropriate for everyone and should only be used as prescribed by a qualified healthcare provider