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Furthermore, the IGF-1 adenovirus vector, transfected to H 2 O 2 -treated hepatocytes, reversed oxidative stress-induced premature senescence via enhancing cytoplasmic AKT1p53 interaction and subsequently inhibiting nuclear p53progerin interaction

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Therapeutic landscape: current advances and translational challenges The past decade has witnessed landmark therapeutic milestones in mitochondrial medicine: Idebenone received European approval for LHON, omaveloxolone became the first FDA-approved therapy for Friedreichs ataxia in 2023, and tofersen achieved regulatory approval for SOD1-associated ALS the same year

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International Diabetes Federation