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GLP-1 therapies uniquely tackle both conditions, delivering the 20.2% weight loss observed with tirzepatide compared with 13.7% for semaglutide in pivotal trials

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Aliquot the reconstituted peptide solution into smaller volumes to avoid thawing the entire solution multiple times

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As mentioned in the IN-formulation section, some aspects of nasal sprays are unique and should be considered carefully during the development process (e.g., formulation, container closure system, stability, manufacturing, intermediates, and drug product)