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461 These neurons also demonstrate increased spontaneous activity independent of ascending afferent input and possess enlarged receptive fields, suggesting that thalamic neurons function as central generators or amplifiers of pain in DPN

ENS-CNS transmission occurs through a sequence of events: [1] local -synuclein seeds form in enteric neurons or associated mucosal cells under conditions of inflammation, oxidative stress, or exposure to microbial/toxic triggers

Antioxidant effects Oxidative stress is a major contributor to the pathogenesis and progression of several GI disorders, such as peptic ulcers, gastritis, IBD, and functional dyspepsia

Tirzepatide (the active ingredient in Mounjaro) has a half-life of roughly 5 days

Does this contain thiamine (vitamin B1)