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It does not bind classical retinoic acid receptors (RARs) the way retinoids do, which is why it carries none of retinol's photosensitivity or purging risk

They dont realize how deadly B12 deficiency can become, and believe they only need to keep patients B12 levels between 150700 pmol/L

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Because DSIP is a small peptide that acts on the central nervous system and is degraded relatively quickly in plasma (for example, one study reported a half-life of ~78 minutes in human plasma)