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Practical recommendations for safe concurrent use include: Take melatonin exactly as prescribed by your doctor (typically Circadin 2mg modified-release tablet) Take melatonin at a consistent time each evening to support circadian rhythm regulation Monitor for any unusual side effects, particularly increased drowsiness or gastrointestinal symptoms If you have diabetes, check blood glucose levels more frequently when first combining these medicines Maintain a sleep diary to track whether melatonin is effectively improving your sleep quality Melatonin may cause drowsiness