tirzepatide surpass-4 Once-weekly versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial Eli Lilly launched a four-dose,

What is the recommended follow-up period in months for patients initiated on Glucagon-like peptide-1 (GLP-1) agonists?

Fat slows digestion further on top of the medication-induced delay, creating a compounding effect that leads to nausea, bloating, and discomfort

Dietary Modifications Certain dietary adjustments may help alleviate bloating: Temporarily reduce intake of gas-producing foods (beans, cruciferous vegetables, carbonated beverages) during the initial adjustment period Ensure adequate hydration (6-8 glasses of fluid daily) to support digestive function If symptoms persist and you have been diagnosed with IBS, consider discussing a low-FODMAP approach with a dietitian, as berberine's effects on gut bacteria may temporarily increase sensitivity to fermentable carbohydrates Increase dietary fibre gradually if constipation contributes to bloating Probiotic Consideration Some individuals find that taking a probiotic supplement alongside berberine helps stabilise gut microbiota and reduce digestive symptoms, though evidence for this approach is limited

Jain et al., 2022)

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