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In summary, the pronounced disparity in DEG counts between semaglutide and tirzepatide is best understood as the outcome of a multifactorial interplay involving (i) distinct pharmacological mechanisms and receptor selectivity, (ii) non-equivalent dosing and consequent differences in transcriptomic breadth, and (iii) biological as well as technical variability, rather than a straightforward difference in therapeutic potency

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Nox2 expression is upregulated in the synovium of RA patients, resulting in continually elevated levels of oxidative stress, which promotes the apoptosis of chondrocytes and the infiltration of inflammatory cells