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An early study in fibroblasts, which identified the three serine doublets in the C-terminal tail of the receptor investigated here as relevant phospho-sites downstream of GRK action, showed a positive correlation between receptor phosphorylation and homologous desensitisation and linked receptor phosphorylation state with its propensity for internalisation (5)

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Therapeutically, these insights underscore the need for microbiome-responsive strategies

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