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The cascade of ROS formation causes oxidative damage to nucleic acid, lipoproteins, cell membranes, and native proteins
Inorganic nitrate is a possible source for systemic generation of nitric oxide
Although this PDT/PARPi combination demonstrates impressive synergistic antitumor and immunostimulatory effects, a more systematic evaluation of its therapeutic window, optimal light dosing, and inclusion of rigorous control groups is needed to fully substantiate its clinical translatability
J Biol Chem 277(18):1598515991 Fraker PJ, Osati-Ashtiani F, Wagner MA, King LE (1995) Possible roles for glucocorticoids and apoptosis in the suppression of lymphopoiesis during zinc deficiency a review
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