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New England Journal of Medicine , 385(6), 503-515

In the OASIS 1 trial, subjects receiving oral semaglutide (50 mg) lost 17.4% of their body weight at 68 weeks , while the placebo group achieved only 1.8% weight loss

SIRT6 complements this function by repressing p66Shc promoter activity and deacetylating histone H3K9Ac, reducing transcription of pro-apoptotic and pro-fibrotic genes 88,89,90

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