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00:16:22 Vickie Danaher For now, wed also want to suggest oral semaglutide in patients who have cardiovascular disease, since semaglutide has the benefit of reducing the risk of MACE or major adverse cardiovascular events like CV death, heart attack, or stroke, but orforglipron doesnt yet have this indication

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However, our experimental studies with GEP44 revealed that interactions with Y1-R could mask the effects of GLP-1R agonism in isolated pancreatic islets